Pubblicazioni in evidenza

2025

• Research Articles

  Tunneling nanotubes between bone marrow stromal cells support transmitophagy and resistance to apoptosis in myeloma Solimando AG*, Di Palma F*, Desantis V, Vacca A, Svelto M, Pisani F. *Equally contributing. Blood Cancer Journal volume 15, Article number: 3 (2025). doi

  A membrane-targeted photoswitch restores physiological ON/OFF responses to light in the degenerate retina Ziraldo G, Cupini S, Sesti V, Delfino E, Lanzani G, Bertarelli C, Benfenati F, Di Marco S. Nat Commun. 2025 Jan 11;16(1):600. doi

  A claudin5-binding peptide enhances the permeability of the blood-brain barrier in vitro Trevisani M, Berselli A, Alberini G, Centonze E, Vercellino S, Cartocci V, Millo E, Ciobanu DZ, Braccia C, Armirotti A, Pisani F, Zara F, Castagnola V, Maragliano L, Benfenati F. Sci Adv. Epub 2025 Jan 10;11(2):eadq2616. doi

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2024

• Research Articles

  Constitutive opening of the Kv7.2 pore activation gate causes KCNQ2 developmental encephalopathy Nappi M, Alberini G, Berselli A, Roscioni A, Soldovieri MV, Servettini I, Barrese V, Weckhuysen S, Chiu TA, Scheffer IE, Benfenati F, Maragliano L, Miceli F, Taglialatela M Proc Natl Acad Sci USA. 2024 Dec 3;121(49):e2412388121. doi

  Inhibition of zDHHC7-driven protein S-palmitoylation prevents cognitive deficits in an experimental model of Alzheimer's disease Natale F, Spinelli M, Rinaudo M, Gulisano W, Nifo Sarrapochiello I, Aceto G, Puzzo D, Fusco S, Grassi C Proc Natl Acad Sci USA. 2024 Dec 3;121(49):e2402604121. doi

  Blockade of dopamine D3 receptors improves hippocampal synaptic function and rescues age-related cognitive phenotype Tropea MR, Melone M, Li Puma DD, Vacanti V, Aceto G, Bandiera B, Trovato RC, Torrisi SA, Leggio GM, Palmeri A, D'Ascenzo M, Conti F, Grassi C, Puzzo D Aging Cell. 2024 Sep 5:e14291. doi

  BV2-derived extracellular vesicles modulate microglia inflammatory profile, neuronal plasticity, and behavioural performances in late adult mice Rinaldi A, Balietti M, Principi E, De Luca M, De Felice E, Narcisi FM, Vilardo L, Rosito M, Piacentini R, D'Alessandro G, D'Agnano I, Maggi L, Conti F, Limatola C, Catalano M Brain Behav Immun. 2024 Nov;122:58-74. doi

  A pH-sensitive closed-loop nanomachine to control hyperexcitability at the single neuron level Merolla A, Michetti C, Moschetta M, Vacca F, Ciano L, Emionite L, Astigiano S, Romei A, Horenkamp S, Berglund K, Gross RE, Cesca F, Colombo E, Benfenati F Nat Commun. 2024 Jul 4;15(1):5609. doi

  Nanoactuator for Neuronal Optoporation Pfeffer ME, DiFrancesco ML, Marchesi A, Galluzzi F, Moschetta M, Rossini A, Francia S, Franz CM, Fok Y, Valotteau C, Paternò GM, Redondo Morata L, Vacca F, Mattiello S, Magni A, Maragliano L, Beverina L, Mattioli G, Lanzani G, Baldelli P, Colombo E, Benfenati F ACS Nano. 2024 May 14;18(19):12427-12452. doi

• Reviews

  Homeostatic regulation of brain activity: from endogenous mechanisms to homeostatic nanomachines Michetti C, Benfenati F Am J Physiol. 2024 Dec 1;327(6):C1384-C1399. doi

  β3-Adrenoceptor Agonism to Mimic the Biological Effects of Intrauterine Hypoxia: Taking Great Strides Toward a Pharmacological Artificial Placenta Filippi L, Innocenti F, Pascarella F, Scaramuzzo RT, Morganti R, Bagnoli P, Cammalleri M, Dal Monte M, Calvani M, Pini A Med Res Rev. 2024 Nov 27. doi

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2023

• Research Articles

  Engineering memory with an extrinsically disordered kinase Ripoli C, Dagliyan O, Renna P, Pastore F, Paciello F, Sollazzo R, Rinaudo M, Battistoni M, Martini S, Tramutola A, Sattin A, Barone E, Saneyoshi T, Fellin T, Hayashi Y, Grassi C Sci Adv. 2023 Nov 17;9(46):eadh1110. doi

  Surgical masks and filtering facepiece class 2 respirators (FFP2) have no major physiological effects at rest and during moderate exercise at 3000 m altitude. A randomised controlled trial Vinetti G, Micarelli A, Falla M, Randi A, Dal Cappello T, Gatterer H, Brugger H, Strapazzon G, Rauch S Journal of Travel Medicine. 2023 Mar 6:taad031. doi

• Reviews

  Nanomedicines to treat rare neurological disorders: The case of Krabbe disease Moore TL, Pannuzzo G, Costabile G, Palange AL, Spanò R, Ferreira M, Graziano ACE, Decuzzi P, Cardile V Adv Drug Deliv Rev.. (2023) Oct 31;203:115132. doi

  The β3 adrenoceptor in proliferative retinopathies: “Cinderella” steps out of its family shadow Cammalleri M, Amato R, Dal Monte M, Filippi L, Bagnoli P Pharmacol Res. (2023) Feb 28;190:106713. doi

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2022

• Research Articles

  Upregulation of Ca2+-binding proteins contributes to VTA dopamine neuron survival in the early phases of Alzheimer’s disease in Tg2576 mice La Barbera L, Nobili A, Cauzzi E, Federici M, Saba L, Giacomet C, Marino R, Krashia P, Melone M, Keller F, Mercuri NB, Viscomi MT, Conti F & D’Amelio M Mol Neurodegeneration. 17, 76 (2022) doi

  Astrocytes mediate long-lasting synaptic regulation of ventral tegmental area dopamine neurons Requie LM, Gómez-Gonzalo M, Speggiorin M, Managò F, Melone M, Congiu M, Chiavegato A, Lia A, Zonta M, Losi G, Henriques VJ, Pugliese A, Pacinelli G, Marsicano G, Papaleo F, Muntoni AL, Conti F, Carmignoto G Nature Neuroscience. (2022) Nov 17 doi

  Morpho-functional analysis of the early changes induced in retinal ganglion cells by the onset of diabetic retinopathy: The effects of a neuroprotective strategy Amato R, Catalani E, Dal Monte M, Cammalleri M, Cervia D, Casini G Pharmacological Research. 185 (2022) 106516 doi

  Role of pericytes in blood-brain barrier preservation during ischemia through tunneling nanotubes Pisani F, Castagnola V, Simone L, Loiacono F, Svelto M, Benfenati F Cell Death Dis. 2022 Jul 5;13(7):582 doi

  Light-induced charge generation in polymeric nanoparticles restores vision in advanced-stage retinitis pigmentosa rats Francia S, Shmal D, Di Marco S, Chiaravalli G, Maya-Vetencourt JF, Mantero G, Michetti C, Cupini S, Manfredi G, DiFrancesco ML, Rocchi A, Perotto S, Attanasio M, Sacco R, Bisti S, Mete M, Pertile G, Lanzani G, Colombo E, Benfenati F Nat Commun. 2022 Jun 27;13(1):3677 doi

  Phenotypic and genetic spectrum of ATP6V1A encephalopathy: a disorder of lysosomal homeostasis Guerrini R, Mei D, Kerti-Szigeti K, Pepe S, Koenig MK, Von Allmen G, Cho MT, McDonald K, Baker J, Bhambhani V, Powis Z, Rodan L, Nabbout R, Barcia G, Rosenfeld JA, Bacino CA, Mignot C, Power LH, Harris CJ, Marjanovic D, Møller RS, Hammer TB; DDD Study, Keski Filppula R, Vieira P, Hildebrandt C, Sacharow S; Undiagnosed Diseases Network, Maragliano L, Benfenati F, Lachlan K, Benneche A, Petit F, de Sainte Agathe JM, Hallinan B, Si Y, Wentzensen IM, Zou F, Narayanan V, Matsumoto N, Boncristiano A, la Marca G, Kato M, Anderson K, Barba C, Sturiale L, Garozzo D, Bei R; ATP6V1A collaborators, Masuelli L, Conti V, Novarino G, Fassio A Brain. 2022 Jun 8:awac145 doi

  Shared population-level dynamics in monkey premotor cortex during solo action, joint action and action observation Pezzulo G, Donnarumma F, Ferrari-Toniolo S, Cisek P, Battaglia-Mayer A Progress in Neurobiology. 210 (2022), 102214 doi

• Reviews

  Environmental enrichment and the aging brain: is it time for standardization? Balietti M, Conti F Neuroscience and Biobehavioral Reviews. (2022) 139:104728 doi

  The posterior parietal area V6A: An attentionally-modulated visuomotor region involved in the control of reach-to-grasp action Galletti C, Gamberini M, Fattori P Neuroscience and Biobehavioral Reviews. 141 (2022) 104823 doi

  The functional characterization of callosal connections Innocenti GM, Schmidt K, Milleret C, Fabri M, Knyazeva MG, Battaglia-Mayer A, Aboitiz F, Ptito M, Caleo M, Marzi CA, Barakovic M, Lepore F, Caminiti R Progress in Neurobiology. 208 (2022) 102186 doi

  Developmental and epileptic encephalopathies: from genetic heterogeneity to phenotypic continuum Guerrini R, Conti V, Mantegazza M, Balestrini S, Galanopoulou AS, Benfenati F Physiol Rev. 2022 Aug 11 doi

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2021

• Research Articles

  Questions about the role of P3HT nanoparticles in retinal stimulation Benfenati F, Lanzani G Nat Nanotechnol. 2021 Dec;16(12):1333-1336 doi

  REST/NRSF drives homeostatic plasticity of inhibitory synapses in a target-dependent fashion Prestigio C, Ferrante D, Marte A, Romei A, Lignani G, Onofri F, Valente P, Benfenati F, Baldelli P Elife. 2021 Dec 2;10:e69058 doi

  REST/NRSF deficiency impairs autophagy and leads to cellular senescence in neurons Rocchi A, Carminati E, De Fusco A, Kowalska JA, Floss T, Benfenati F Aging Cell. 2021 Oct;20(10):e13471 doi

  PRRT2 modulates presynaptic Ca2+ influx byinteracting with P/Q-type channels Ferrante D, Sterlini B, Prestigio C, Marte A, Corradi A, Onofri F, Tortarolo G, Vicidomini G, Petretto A, Muià J, Thalhammer A, Valente P, Cingolani LA, Benfenati F, Baldelli P Cell Rep. 2021 Jun 15;35(11):109248 doi

  Genetic deletion of α7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer's disease-like pathology Tropea MR, Li Puma DD, Melone M, Gulisano W, Arancio O, Grassi C, Conti F, Puzzo D Prog Neurobiol. 2021 Aug 25:102154 doi

  Motor-like neural dynamics in two parietal areas during arm reaching Diomedi S, Vaccari FE, Galletti C, Hadjidimitrakis K, Fattori P Prog Neurobiol.  (Available online 2 July 2021, 102116) In press doi

  Defects of full-length dystrophin trigger retinal neuron damage and synapse alterations by disrupting functional autophagy Catalani E, Bongiorni S, Taddei AR, Mezzetti M, Silvestri F, Coazzoli M, Zecchini S, Giovarelli M, Perrotta C, De Palma C, Clementi E, Ceci M, Prantera G, Cervia D. Cell Mol Life Sci. 2021 Feb;78(4):1615-1636 doi

  Nilotinib restores memory function by preventing dopaminergic neuron degeneration in a mouse model of Alzheimer’s Disease La Barbera L, Vedele F, Nobili A, Krashia P, Spoleti E, Latagliata EC, Cutuli D, Cauzzi E, Marino R, Viscomi MT, Petrosini L, Puglisi-Allegra S, Melone M, Keller F, Mercuri NB, Conti F, D'Amelio M Prog Neurobiol. 2021 Mar 5;102031 doi

  Non-canonical glutamate signaling in a genetic model of migraine with aura Parker PD, Suryavanshi P.,Melone M, Reinhart KM, Sawant-Pokam PM, Kaufmann D, Theriot JJ, Pugliese A, Conti F, Shuttleworth CW, Pietrobon D, Brennan KC Neuron 2021 Feb 17; 109(4):563-565 doi

  Contralateral Effects of Unilateral Strength and Skill Training: Modified Delphi Consensus to Establish Key Aspects of Cross-Education Manca A, Hortobágyi T, Carroll TJ, Enoka RM, Farthing JP, Gandevia SC, Kidgell DJ, Taylor JL, Deriu F. Sports Med. 2021 Jan;51(1):11-20 doi

• Reviews

  Clinical translation of nanoparticles for neural stimulation Benfenati F, Lanzani G Nature Reviews Materials. 2021 6: 1-4 doi

  β3‐Adrenoceptor, a novel player in the round‐trip from neonatal diseases to cancer: Suggestive clues from embryo Filippi L, Pini A, Cammalleri M, Bagnoli P, Dal Monte M Med Res Rev. 2021;1-23 doi

  Clinical translation of nanoparticles for neural stimulation Benfenati F, Lanzani G Nature Reviews Materials. 2021 6: 1-4 doi

  Regulation of STAT3 and its role in cardioprotection by conditioning: focus on non-genomic roles targeting mitochondrial function Comità S, Femmino S, Thairi C, Alloatti G, Boengler K, Pagliaro P, Penna C Basic Research in Cardiology 2021 116:56 doi

  Be cool to be far: Exploiting hibernation for space exploration Cerri M, Hitrec T, Luppi M, Amici R Neurosci Biobehav Rev. 2021 Jun 16;128:218-232 doi · paper

  Effects of insomnia and restless legs syndrome on sleep arterial blood pressure: A systematic review and meta-analysis Maiolino G, Bisogni V, Soranna D, Fengo MF, Pucci G, Vettor R, Fava C, Colussi GL, Bilo G, Silvani C, Parati G, Rossi GP, Silvani A Sleep Medicine Review 59 (2021) 101497 doi · libero accesso al paper per 30 gg

  Presynaptic protein synthesis and brain plasticity: from physiology to neuropathology Perrone-Capano C, Volpicelli F, Penna E, Chun JT, Crispino M Prog Neurobiol. 2021 Apr 9:102051 doi · libero accesso al paper per 50 gg

  Consensus Guidelines on Rodent Models of Restless Legs Syndrome Salminen AV, Silvani AS, Richard PA, Stefan Clemens C, Garcia‐Borreguero D, Ghorayeb I, Ferrè S; Ondo W, Picchietti DL, Rye D, Siegel JM, Manconi M, International Restless Legs Syndrome Study Group (IRLSSG) Mov. Dis. 31 Dec 2020 doi